解答:解:如图,以A为原点,以AB为x轴,AD为y轴,AP为z轴,建立空间直角坐标系,∵PA=AD=2,E,F分别是线段AB,BC的中点,∴P(0,0,2),E(1,0,0),F(2,1,0),D(0,2,0),∴ PE =(1,0,?2), FD =(?2,1,0),设PE与FD所成角为θ,则cosθ=|cos< PE , FD >|=| ?2 5 ? 5 |= 2 5 .故选:C.